Key result
Deteriorating glucose tolerance in women was associated with increased left ventricular mass (157 g in normal vs 169 g in type 2 diabetes; P for trend <0.018), independent of arterial stiffness.
Why the study?
Does deteriorating glucose tolerance status increase left ventricular mass independently of arterial stiffness or endothelial dysfunction?
Cross-Sectional (n=780)
Does deteriorating glucose tolerance status increase left ventricular mass independently of arterial stiffness or endothelial dysfunction?
Absolute Event Rate: 169% vs 157%
p-value: p=<0.018
Deteriorating glucose tolerance is associated with increased left ventricular mass in women, independent of arterial stiffness or endothelial dysfunction, potentially explaining their increased cardiovascular risk.
Authors
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Should not yet change practice; hypothesis-generating for sex-specific LV remodeling in dysglycemia.
Henry et al. (2004) conducted a cross-sectional in Type 2 diabetes and impaired glucose metabolism (n=780). Deteriorating glucose tolerance status vs. Normal glucose metabolism was evaluated on Left ventricular mass (LVM) (p=<0.018). Deteriorating glucose tolerance in women was associated with increased left ventricular mass (157 g in normal vs 169 g in type 2 diabetes; P for trend <0.018), independent of arterial stiffness.
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