Key result
High plasma prorenin activity predicted the development of retinopathy or overt albuminuria, occurring in 57.1% of patients with high values compared to 5.0% with consistently normal values.
Why the study?
Does high plasma prorenin activity predict the development of retinopathy or nephropathy in children and adolescents with Type I diabetes?
Population
135 children and adolescents with Type I diabetes mellitus, including a prospective cohort of 34 patients…
Comparison
High plasma prorenin activity vs Consistently normal plasma prorenin activity
Design
Cohort
Follow-up
6 to 39 months
Authors
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Supports prorenin as a microvascular risk marker in youth with T1D; leaves open prospective validation before clinical use.
Cohort (n=135)
Does high plasma prorenin activity predict the development of retinopathy or nephropathy in children and adolescents with Type I diabetes?
Absolute Event Rate: 57.1% vs 5%
Wilson et al. (1990) conducted a cohort in Insulin-Dependent (Type I) Diabetes Mellitus (n=135). High plasma prorenin activity vs. Consistently normal plasma prorenin values was evaluated on Retinopathy or overt albuminuria. High plasma prorenin activity predicted the development of retinopathy or overt albuminuria, occurring in 57.1% of patients with high values compared to 5.0% with consistently normal values.
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