What question did this study set out to answer?

This research aimed to examine plasma prorenin levels in patients with and without diabetes experiencing autonomic dysfunction.

May 1, 1987The Journal of Clinical Endocrinology & Metabolism

Elevated Levels of Plasma Prorenin (Inactive Renin) in Diabetic and Nondiabetic Patients with Autonomic Dysfunction*

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Why the study?

Is autonomic dysfunction associated with elevated plasma inactive renin levels in diabetic and nondiabetic patients?

Population

165 subjects, including 46 diabetic patients, 4 nondiabetic patients with idiopathic autonomic dysfunction…

Design

Cross-sectional

Authors

RMRobert I. MisbinJohns Hopkins University MGMaria B. GrantUniversity of Alabama at Birmingham MPMark S. PeckerCornell University

Discussion

Member takes

Implication

Autonomic dysfunction was associated with elevated inactive renin independent of glycemia; hypothesis-generating and should not yet change practice.

Key Points

This research aimed to examine plasma prorenin levels in patients with and without diabetes experiencing autonomic dysfunction.
Measured plasma inactive renin levels in 46 diabetic patients and 4 nondiabetic patients with autonomic dysfunction.
Compared levels with 115 normal subjects and analyzed correlations with glycemic control using hemoglobin A1c.
Categorized diabetic patients based on the presence or absence of complications and autonomic dysfunction.
Diabetic patients with autonomic dysfunction exhibited elevated or upper normal plasma prorenin levels (n=18).
No correlation was observed between plasma prorenin levels and glycemic control (P>0.05).
Nondiabetic patients with idiopathic autonomic dysfunction also showed high plasma prorenin levels (n=4).

Structured PICO

Is autonomic dysfunction associated with elevated plasma inactive renin levels in diabetic and nondiabetic patients?

Population

165 subjects, including 46 diabetic patients (n=6 with no complications, n=8 with microvascular disease but no autonomic dysfunction, n=18 with autonomic dysfunction), 4 nondiabetic patients with idiopathic autonomic dysfunction, and 115 normal subjects.

Comparator

Normal subjects and diabetic patients without autonomic dysfunction

Outcome

Plasma inactive renin (prorenin) levelssurrogate

Elevated plasma inactive renin (prorenin) levels in diabetic patients appear to be driven by coexistent autonomic dysfunction rather than glycemic control or microvascular disease alone.

Cite This Study

Misbin et al. (1987) studied this question.

synapsesocial.com/papers/6a6fde3431a3df8243282c42 https://doi.org/10.1210/jcem-64-5-964

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Implication

Autonomic dysfunction was associated with elevated inactive renin independent of glycemia; hypothesis-generating and should not yet change practice.

Elevated Levels of Plasma Prorenin (Inactive Renin) in Diabetic and Nondiabetic Patients with Autonomic Dysfunction*

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Elevated Levels of Plasma Prorenin (Inactive Renin) in Diabetic and Nondiabetic Patients with Autonomic Dysfunction*

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider