Population
78 subjects: 37 patients with early type 1 diabetes and 41 age-matched control subjects.
Design
Cohort
Follow-up
3 years
Authors
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Suggests early prorenin processing defect in type 1 diabetes; leaves open its utility for microvascular risk prediction.
Abnormal processing of prorenin develops in type 1 diabetic patients prior to microvascular disease and before the first evidence of autonomic dysfunction.
Hoeldtke et al. (2000) studied this question.
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