Why the study?
Does baseline autonomic dysfunction predict the progression of renal disease in type 1 diabetic patients with proteinuria?
Population
26 type 1 diabetic patients with proteinuria
Comparison
Abnormal autonomic function at baseline vs Normal autonomic function at baseline
Design
Cohort
Follow-up
12 months
Authors
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Autonomic dysfunction was associated with rising creatinine in proteinuric type 1 diabetes; hypothesis-generating for predictive value and targeted interventions.
Does baseline autonomic dysfunction predict the progression of renal disease in type 1 diabetic patients with proteinuria?
Abnormal autonomic function, particularly an abnormal Valsalva maneuver, identifies type 1 diabetic patients with proteinuria at high risk for rapid renal deterioration who may benefit from aggressive blood pressure lowering.
Larry A. Weinrauch (1998) studied this question.
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