What question did this study set out to answer?

Investigate how the intestinal microbiota influences host cholesterol homeostasis and circulation at the organism scale.

November 27, 2019BMC BiologyOpen Access

The intestinal microbiota regulates host cholesterol homeostasis

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Authors

TRTiphaine Le RoyInserm ELEmelyne LécuyerInserm BCBenoît ChassaingCentre National de la Recherche Scientifique

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Implication

Experimental study reveals gut microbiota regulation of plasma cholesterol and hepatic synthesis in mice, highlighting microbial targets for treating dyslipidemia.

Key Points

Investigate how the intestinal microbiota influences host cholesterol homeostasis and circulation at the organism scale.
Depleted gut microbiota in mice using broad-spectrum antibiotics to measure alterations in plasma cholesterol levels, synthesis rates, and metabolic fluxes.
Transplanted fecal microbiota from humans with elevated plasma cholesterol into recipient mice and correlated recipient phenotypes with specific bacterial phylotypes.
Gut microbiota depletion showed that intestinal microbes strongly regulate plasma cholesterol levels, hepatic cholesterol synthesis, and enterohepatic circulation.
Fecal microbiota transplantation from hypercholesterolemic human donors induced elevated plasma cholesterol, reduced hepatic cholesterol synthesis, and increased intestinal cholesterol absorption in recipient mice.
Recipient phenotypic shifts significantly correlated with specific bacterial taxa belonging to Betaproteobacteria, Alistipes, Bacteroides, and Barnesiella.

Cite This Study

Roy et al. (2019) studied this question.

synapsesocial.com/papers/6a0df2511e1a6dfdb4baf426 https://doi.org/10.1186/s12915-019-0715-8

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Implication

Experimental study reveals gut microbiota regulation of plasma cholesterol and hepatic synthesis in mice, highlighting microbial targets for treating dyslipidemia.

The intestinal microbiota regulates host cholesterol homeostasis

Discussion

Member takes

Implication

Key Points

Cite This Study

The intestinal microbiota regulates host cholesterol homeostasis

Discussion

Member takes

Implication

Key Points

Cite This Study

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