What question did this study set out to answer?

To review the development of experimental adjunctive therapies for septic shock and discuss strategies with potential clinical utility.

January 1, 1995Clinical Infectious Diseases

Adjunctive Therapy for Septic Shock: A Review of Experimental Approaches

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Authors

WLWilliam LynnMaidstone and Tunbridge Wells NHS Trust JCJonathan B. CohenState University of New York

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Implication

Review outlines experimental adjunctive treatments targeting pathogens, inflammation, and tissue injury in septic shock, highlighting the potential of stage-specific combination regimens.

Key Points

To review the development of experimental adjunctive therapies for septic shock and discuss strategies with potential clinical utility.
Synthesized findings from preclinical models and early clinical evaluations of adjunctive sepsis interventions.
Categorized therapeutic mechanisms into strategies targeting bacterial components, host-derived inflammatory mediators, and tissue damage prevention.
No experimental adjunctive therapy demonstrating preclinical efficacy in animal models has achieved approval for human clinical use.
Effective therapeutic modification requires stage-specific and multitarget combination strategies tailored to the evolving pathogenesis of septic shock.

Cite This Study

Lynn et al. (1995) studied this question.

synapsesocial.com/papers/6a0df25668ddba849a09f2d3 https://doi.org/10.1093/clinids/20.1.143

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Implication

Review outlines experimental adjunctive treatments targeting pathogens, inflammation, and tissue injury in septic shock, highlighting the potential of stage-specific combination regimens.

Adjunctive Therapy for Septic Shock: A Review of Experimental Approaches

Discussion

Member takes

Implication

Key Points

Cite This Study

Adjunctive Therapy for Septic Shock: A Review of Experimental Approaches

Discussion

Member takes

Implication

Key Points

Cite This Study

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