Key result
AT1R blockade with valsartan lowered systolic blood pressure by 30%, albuminuria by 91%, and kidney MDA by 80% in Ren2 rats compared with untreated controls.
Why the study?
Does valsartan reduce albuminuria and oxidative stress while improving glomerular filtration barrier integrity in Ren2 transgenic rats?
Does valsartan reduce albuminuria and oxidative stress while improving glomerular filtration barrier integrity in Ren2 transgenic rats?
AT1R blockade with valsartan reduces blood pressure, albuminuria, and tissue oxidative stress while improving glomerular filtration barrier integrity in a transgenic rat model of hypertension.
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Valsartan benefits in Ren2 rats are hypothesis-generating; leaves open translation to human hypertensive nephropathy.
Whaley‐Connell et al. (2006) studied Hypertension and glomerular filtration barrier injury. Valsartan vs. Untreated Ren2 and Sprague-Dawley rats was evaluated on Systolic blood pressure, albuminuria, and kidney malondialdehyde (MDA). AT1R blockade with valsartan lowered systolic blood pressure by 30%, albuminuria by 91%, and kidney MDA by 80% in Ren2 rats compared with untreated controls.
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