Key result
Both renin inhibition with aliskiren and AT1R blockade with irbesartan significantly attenuated myocardial perivascular fibrosis and NADPH oxidase activity in transgenic Ren2 rats.
Why the study?
Does renin inhibition or AT1R blockade reduce myocardial oxidative stress and remodeling in a transgenic rat model of chronically elevated tissue Angiotensin II?
Does renin inhibition or AT1R blockade reduce myocardial oxidative stress and remodeling in a transgenic rat model of chronically elevated tissue Angiotensin II?
Absolute Event Rate: 45.4% vs 61.1%
p-value: p=<0.05
In a transgenic rat model of elevated tissue Angiotensin II, both direct renin inhibition and AT1R blockade effectively attenuated myocardial NADPH oxidase activity, oxidative stress, and structural remodeling.
No takes yet. Share an insight, caveat, or question.
Renin inhibition or AT1R blockade may limit fibrosis in Ang II-driven models; leaves open translation to human hypertensive heart disease.
Whaley‐Connell et al. (2008) studied Myocardial remodeling and oxidative stress in hypertension. Aliskiren and Irbesartan vs. Placebo was evaluated on Perivascular fibrosis (percent adventitial area per vessel) (p=<0.05). Both renin inhibition with aliskiren and AT1R blockade with irbesartan significantly attenuated myocardial perivascular fibrosis and NADPH oxidase activity in transgenic Ren2 rats.
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