Key result
Lower serum corin is linked to reduced peak VO2 in advanced heart failure.
Why the study?
Corin is a cardiac protease that transforms pro-natriuretic peptides into active forms, but its relationship with functional capacity in advanced heart failure remains to be investigated.
Are serum corin levels associated with functional capacity (peak VO₂) in patients with advanced heart failure?
Cross-Sectional (n=88)
No
Are serum corin levels associated with functional capacity (peak VO₂) in patients with advanced heart failure?
Lower serum corin levels are independently associated with reduced functional capacity in advanced heart failure, suggesting its potential utility as a biomarker alongside CPET.
May complement CPET for functional assessment in advanced HF; leaves open incremental value in prospective studies.
BACKGROUND: Corin is a cardiac protease that plays a role in transforming pro-natriuretic peptides into their active biological forms. This study aimed to investigate the relationship between serum corin levels and functional capacity in patients with advanced heart failure. METHODS: This cross-sectional study included 88 consecutive patients with LVEF (Left ventricular ejection fraction) <25% who were referred to the tertiary cardiovascular center. Serum corin levels were measured using ELISA (Enzyme-linked immunosorbent assay) prior to CPET (Cardiopulmonary exercise testing). Multivariable linear regression was used to assess the independent association between serum corin levels and peak VO₂ (Peak oxygen consumption). CONCLUSION: Lower serum corin levels are independently associated with reduced functional capacity in advanced heart failure. Corin may serve as a valuable biomarker to complement CPET in clinical evaluation, risk stratification, and treatment planning.
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Karaçam et al. (2025) conducted a cross-sectional in advanced heart failure (n=88). Serum corin levels was evaluated on Peak VO2 (Peak oxygen consumption) (p=0.0007). Lower serum corin levels were independently associated with reduced functional capacity (peak VO2) in patients with advanced heart failure (P=0.0007).
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