Key result
Lower CORIN levels linked to HF, suggesting potential utility in diagnosis.
Why the study?
The study was conducted to evaluate the association between CORIN and heart failure.
Are CORIN levels associated with the presence and severity of heart failure?
Meta-Analysis
Are CORIN levels associated with the presence and severity of heart failure?
CORIN levels are significantly altered in patients with heart failure compared to controls, suggesting potential utility as a diagnostic biomarker.
May support CORIN as HF diagnostic biomarker; leaves open prospective validation of clinical utility.
Objectives: We aim to evaluate the association between CORIN and heart failure. Methods: This study used PubMed, EMBASE, Cochrane database, and China National Knowledge Database (CNKI) to search for CORIN-related full-text articles with heart failure patients. We drew forest plots, performed sensitivity and bias analyses based on the included data. Next, we used Review Manager 5.2 software to assess the heterogeneity among selected articles. Results: Our meta-analysis results showed there was significant relationship between CORIN and heart failure (HF). There was significant difference of CORIN between heart failure group and control group (MD = −293.88, 95% confidence interval [-380.26, −207.49], p < .00001; heterogeneity p < .0001, I 2 = 97%) and there was significant difference in CORIN between ischemic group and non-ischemic group (MD = 88.79, 95% confidence interval [70.46107.12], heterogeneity p < .000, p = 0.94, l 2 = 0%). In subgroup analysis, there were significant differences in three different HF levels. Limited publication bias was observed, and this study was robust. Conclusion: In short, the results showed that CORIN was closely related with heart failure and might be helpful in the diagnosis of heart failure.
No takes yet. Share an insight, caveat, or question.
Jiang et al. (2022) conducted a meta-analysis in Heart failure. CORIN vs. Control group was evaluated on Difference in CORIN levels between heart failure group and control group (MD -293.88, 95% CI -380.26, -207.49, p=< .00001). CORIN levels were significantly lower in patients with heart failure compared to controls (MD -293.88; 95% CI -380.26 to -207.49; p<0.00001), suggesting its potential utility in diagnosis.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: