Key result
An age-dependent ratio of R-R intervals during deep breathing accurately diagnosed autonomic neuropathy in diabetics, yielding only 6 false-negative and 1 false-positive results.
Why the study?
Does an age-related normal range for the deep breathing test accurately diagnose autonomic neuropathy in diabetic patients?
Population
174 healthy subjects aged 16-89 years and 134 diabetics aged 15-70 years with various degrees of neuropathy.
Design
Cross-sectional
Authors
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May support age-adjusted deep breathing test for diabetic autonomic neuropathy screening; hypothesis-generating, requires prospective validation before practice change.
Cross-Sectional (n=308)
Does an age-related normal range for the deep breathing test accurately diagnose autonomic neuropathy in diabetic patients?
p-value: p=<0.001
An age-adjusted expiration/inspiration R-R ratio during deep breathing provides a simple and accurate electrocardiographic screening tool for diabetic autonomic neuropathy.
Stephanie A. Smith (1982) conducted a cross-sectional in Diabetic autonomic neuropathy (n=308). Deep breathing test (R-R interval ratio) vs. Healthy subjects was evaluated on Ratio of longest R-R interval during expiration to shortest R-R interval during inspiration (p=<0.001). An age-dependent ratio of R-R intervals during deep breathing accurately diagnosed autonomic neuropathy in diabetics, yielding only 6 false-negative and 1 false-positive results.
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