Key result
The mean difference between maximal and minimal heart rate during deep breathing was the most sensitive index for diabetic autonomic neuropathy, showing an abnormal response in 38% of diabetic patients.
Why the study?
Does the measurement of heart rate variations during rest, deep breathing, and standing accurately detect autonomic neuropathy in diabetic patients compared to healthy subjects?
Population
168 diabetics and 162 healthy subjects (n=330)
Comparison
Measurement of heart rate variations using an… vs Healthy subjects
Design
Cross-sectional
Authors
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May support heart rate variation testing in diabetes; hypothesis-generating and requires prospective validation before practice change.
Cross-Sectional (n=330)
Does the measurement of heart rate variations during rest, deep breathing, and standing accurately detect autonomic neuropathy in diabetic patients compared to healthy subjects?
The mean difference between maximal and minimal heart rate during deep breathing (delta I-E) is the most sensitive index for detecting diabetic autonomic neuropathy and should be measured alongside heart rate increase on standing.
Oikawa et al. (1985) conducted a cross-sectional in Diabetic autonomic neuropathy (n=330). Diabetes vs. Healthy subjects was evaluated on Incidence of abnormal response in mean difference between maximal and minimal heart rate during deep breathing (ΔI-E). The mean difference between maximal and minimal heart rate during deep breathing was the most sensitive index for diabetic autonomic neuropathy, showing an abnormal response in 38% of diabetic patients.
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