What question did this study set out to answer?

This study aims to assess cardiac autonomic function using heart-rate variability in diabetic subjects compared to controls.

October 1, 1990Diabetes

Heart-Rate Variability and Cardiac Autonomic Function in Diabetes

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Why the study?

Does 24-hour heart-rate variability monitoring detect changes in cardiac autonomic function compared to standard tests in patients with insulin-dependent diabetes mellitus?

Population

36 subjects, including 25 with insulin-dependent diabetes mellitus and 11 control subjects.

Comparison

24-hour heart-rate variability monitoring via… vs Standard tests of autonomic function

Design

Case-control

Follow-up

24 hours

Authors

SMSimon C. MalpasUniversity of Auckland MTMaling TjVictoria University of Wellington

Discussion

Member takes

Implication

Reduced HRV despite normal standard tests supports greater sensitivity of 24-hour monitoring in diabetes; leaves open its role in risk stratification.

Key Points

This study aims to assess cardiac autonomic function using heart-rate variability in diabetic subjects compared to controls.
Measured cardiac autonomic function in 25 subjects with diabetes and 11 controls.
Divided diabetic subjects based on vagal neuropathy status using autonomic function tests.
Monitored subjects with ambulatory electrocardiographs for 24 hours to analyze heart-rate variability.
HRV was significantly reduced in group 1 (73 +/- 9 ms) and group 2 (65 +/- 12 ms) diabetic subjects compared to controls (138 +/- 10 ms).
Standard tests did not identify vagal dysfunction in group 1 diabetic subjects as clearly as HRV monitoring.
24-hour HRV measurement can detect subtle changes in cardiac autonomic function.

Structured PICO

Does 24-hour heart-rate variability monitoring detect changes in cardiac autonomic function compared to standard tests in patients with insulin-dependent diabetes mellitus?

Population

36 subjects, including 25 with insulin-dependent diabetes mellitus (selected based on peripheral or autonomic neuropathy or long-term poorly controlled diabetes) and 11 control subjects.

Intervention

24-hour heart-rate variability (HRV) monitoring via ambulatory electrocardiograph

Comparator

Standard tests of autonomic function

Outcome

Heart-rate variability (HRV) measured from the standard deviation of the successive differences between R-R intervalssurrogate

24-hour HRV monitoring is more sensitive than standard autonomic function tests for detecting early cardiac autonomic dysfunction in patients with insulin-dependent diabetes mellitus.

Cite This Study

Malpas et al. (1990) studied this question.

synapsesocial.com/papers/6a6f9506f44fa9f079dd0af8 https://doi.org/10.2337/diab.39.10.1177

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Implication

Reduced HRV despite normal standard tests supports greater sensitivity of 24-hour monitoring in diabetes; leaves open its role in risk stratification.

Heart-Rate Variability and Cardiac Autonomic Function in Diabetes

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Heart-Rate Variability and Cardiac Autonomic Function in Diabetes

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider