Diabetes mellitus was associated with lower time-domain and frequency-domain heart rate variability parameters compared to healthy controls, with further reductions in those with chronic complications.
Case-Control (n=61)
Does diabetes mellitus reduce heart rate variability compared to healthy controls?
Diabetes mellitus is associated with reduced heart rate variability, indicative of cardiovascular autonomic neuropathy, which is more pronounced in patients with chronic complications.
Diabetes mellitus can cause cardiovascular autonomic neuropathy and is associated with increased cardiovascular deaths. We investigated cardiovascular autonomic neuropathy in diabetics and healthy controls by analysis of heart rate variability. Thirty-one diabetics and 30 age- and sex-matched controls were included. In the time domain we measured the mean R - R interval (NN), the standard deviation of the R - R interval index (SDNN), the standard deviation of the 5-min R - R interval mean (SDANN), the root mean square of successive R - R interval differences (RMSSD) and the percentage of beats with a consecutive R - R interval difference > 50 ms (pNN50). In the frequency domain we measured high-frequency power (HF), low-frequency power (LF) and the LF/HF ratio. Diabetes patients had lower values for time-domain and frequency-domain parameters than controls. Most heart rate variability parameters were lower in diabetes patients with chronic complications than in those without chronic complications.
Kudat et al. (Mon,) conducted a case-control in Diabetes mellitus (n=61). Diabetes mellitus vs. Healthy controls was evaluated on Heart rate variability (time-domain and frequency-domain parameters). Diabetes mellitus was associated with lower time-domain and frequency-domain heart rate variability parameters compared to healthy controls, with further reductions in those with chronic complications.