What question did this study set out to answer?

October 1, 1986QJM

The Prevalence of Autonomic Neuropathy in Insulin-dependent Diabetes Mellitus: A Controlled Study Based on Heart Rate Variability

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Why the study?

What is the prevalence of autonomic neuropathy in insulin-dependent diabetics compared to non-diabetic controls based on heart rate variability?

Population

506 unselected insulin-dependent diabetics aged 12 to 85 years

Comparison

Heart rate variability measurement by a… vs 310 non-diabetic control subjects aged 18 to 87…

Design

Cross-sectional

Authors

IOI A O'BrienBristol Royal Infirmary JOJAMES P. OʼHAREUniversity Hospital of North Tees ILI.G. LewinNorth Devon District Hospital

Discussion

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Implication

May warrant autonomic testing in long-standing insulin-dependent diabetes; leaves open whether detection improves outcomes in prospective studies.

Key Points

This study aims to determine the prevalence of autonomic neuropathy in insulin-dependent diabetics through heart rate variability assessments.
Investigated autonomic function using heart rate variability tests in 506 insulin-dependent diabetics.
Measured heart rate variability during rest, deep breath, valsalva manoeuvre, and standing.
Compared heart rate responses to age-related normal ranges from 310 non-diabetic controls.
Found that 16.6% of diabetics had abnormal autonomic scores, indicating cardiac autonomic denervation.
Impaired heart rate variability was most common in response to a single deep breath, with 24.5% in ages 40-49.
Abnormal scores significantly correlated with the duration of diabetes (p < 0.0001) but not with age (p = 0.06).

Structured PICO

What is the prevalence of autonomic neuropathy in insulin-dependent diabetics compared to non-diabetic controls based on heart rate variability?

Population

506 unselected insulin-dependent diabetics aged 12 to 85 years

Intervention

Heart rate variability measurement by a computerised technique during rest, single deep breath, Valsalva manoeuvre, and standing

Comparator

310 non-diabetic control subjects aged 18 to 87 years

Outcome

Prevalence of autonomic neuropathy (defined as an autonomic score of 2 or more)surrogate

Cardiac autonomic denervation is prevalent in approximately 16.6% of insulin-dependent diabetics and correlates strongly with the duration of the disease.

Cite This Study

O'Brien et al. (1986) studied this question.

synapsesocial.com/papers/6a70744226a7f98052dcf4cd https://doi.org/10.1093/oxfordjournals.qjmed.a068054

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Implication

May warrant autonomic testing in long-standing insulin-dependent diabetes; leaves open whether detection improves outcomes in prospective studies.

The Prevalence of Autonomic Neuropathy in Insulin-dependent Diabetes Mellitus: A Controlled Study Based on Heart Rate Variability

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

The Prevalence of Autonomic Neuropathy in Insulin-dependent Diabetes Mellitus: A Controlled Study Based on Heart Rate Variability

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider