What question did this study set out to answer?

To determine the prevalence of cardiovascular autonomic dysfunction in newly diagnosed IDDM compared to healthy controls.

July 1, 1992Diabetes Care

Prevalence of Cardiovascular Autonomic Dysfunction Assessed by Spectral Analysis and Standard Tests of Heart-Rate Variation in Newly Diagnosed IDDM Patients

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Why the study?

Is cardiovascular autonomic dysfunction more prevalent in newly diagnosed IDDM patients compared to healthy nondiabetic subjects?

Population

130 newly diagnosed insulin-dependent diabetes mellitus patients aged 12-40 years, after insulin…

Comparison

Assessment of cardiovascular autonomic nerve… vs 120 healthy nondiabetic subjects.

Design

Case-control

Authors

DZDan ZieglerElectrophysiology KDKarsten DannehlHeinrich Heine University Düsseldorf HMH MühlenBG Klinikum Duisburg

Discussion

Member takes

Implication

Autonomic neuropathy appears early in new-onset IDDM; leaves open whether routine testing improves outcomes.

Key Points

To determine the prevalence of cardiovascular autonomic dysfunction in newly diagnosed IDDM compared to healthy controls.
Evaluated 130 newly diagnosed IDDM patients aged 12-40 years using cardiovascular reflex tests and heart-rate variation metrics.
Defined age-dependent normal limits from 120 nondiabetic subjects for test comparison.
Conducted additional measurements of autonomic response in 50 patients.
Diabetic patients had a significantly higher prevalence of abnormal low-frequency (7.3% vs. 0.8%, P<0.05) and mid-frequency (10.6% vs. 0%, P<0.001) test responses.
Higher Valsalva ratio abnormalities in IDDM patients (17.5% vs. 4.2%, P<0.001).
In total, 7.7% of diabetic patients met criteria for cardiovascular autonomic neuropathy vs. none in nondiabetic controls (P<0.001).

Structured PICO

Is cardiovascular autonomic dysfunction more prevalent in newly diagnosed IDDM patients compared to healthy nondiabetic subjects?

Population

130 newly diagnosed insulin-dependent diabetes mellitus (IDDM) patients aged 12-40 years, after insulin administration for 3-39 days with mean blood glucose 7.2 mM.

Intervention

Assessment of cardiovascular autonomic nerve dysfunction using a battery of cardiovascular reflex tests, including spectral analysis and standard tests of heart-rate variation (HRV).

Comparator

120 healthy nondiabetic subjects.

Outcome

Prevalence of cardiovascular autonomic nerve dysfunction (abnormal test responses in HRV and spectral analysis).surrogate

Cardiovascular autonomic nerve dysfunction is relatively common in newly diagnosed IDDM patients and can be detected early using a combination of spectral and conventional HRV analysis.

Cite This Study

Ziegler et al. (1992) studied this question.

synapsesocial.com/papers/6a7a4c5be357fbdac589737b https://doi.org/10.2337/diacare.15.7.908

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Prevalence of Cardiovascular Autonomic Dysfunction Assessed by Spectral Analysis and Standard Tests of Heart-Rate Variation in Newly Diagnosed IDDM Patients

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Prevalence of Cardiovascular Autonomic Dysfunction Assessed by Spectral Analysis and Standard Tests of Heart-Rate Variation in Newly Diagnosed IDDM Patients

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider