Key result
Higher VCAM-1 is linked to inadequate HbA1c and altered lipids, suggesting early diabetic endothelial damage.
Why the study?
Biomarkers can help understand the impact of achieving therapeutic goals in developing vascular diseases in diabetics.
Are lipid and glycemic profiles associated with endothelial biomarkers in diabetic patients?
Cross-Sectional
Are lipid and glycemic profiles associated with endothelial biomarkers in diabetic patients?
In diabetic patients, elevated VCAM-1 is associated with inadequate glycemic and lipid control, suggesting early endothelial damage.
Supports VCAM-1 as endothelial marker in uncontrolled diabetes; leaves open causal and prognostic roles pending prospective studies.
Background: Biomarkers can help understand the impact of achieving therapeutic goals in developing vascular diseases in diabetics. Aim: To assess the association between lipid and glycemic profiles and endothelial biomarkers in diabetics. Methods: Cross-sectional study that evaluated lipid and glycemic levels and biomarkers (VCAM-1, Sdc-1, FGF-23 and KIM-1 in diabetics. Results: Higher VCAM-1 levels were associated with higher low-density lipoprotein cholesterol and non-high-density lipoprotein (HDL) cholesterol levels (in the group with inadequate glycohemoglobin A1c [HbA1c] levels), with higher glycemic levels (in the group with inadequate HDL cholesterol levels) and with lower HDL cholesterol levels (both groups). VCAM-1 was independently associated with not achieving adequate HbA1c levels. Conclusion: In uncontrolled diabetics, VCAM-1 was independently associated with having inadequate HbA1c levels, suggesting they may already have endothelial damage.
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Néri et al. (2023) conducted a cross-sectional in Diabetic patients. Endothelial biomarkers (VCAM-1, Sdc-1, FGF-23, KIM-1) was evaluated on Association between lipid and glycemic profiles and endothelial biomarkers. Higher VCAM-1 levels were independently associated with inadequate HbA1c levels and altered lipid profiles in diabetic patients, suggesting early endothelial damage.
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