Key result
Type 1 diabetes is linked to significantly higher serum VCAM-1 levels regardless of cardiovascular disease.
Why the study?
High glucose levels in diabetes are associated with increased soluble adhesion molecules that may contribute to premature atherosclerosis and microvascular complications, but the relationship of VCAM-1 with cardiovascular disease and diabetic parameters in type 1 diabetes mellitus patients is not fully understood.
Population
60 type 1 diabetic patients with and without cardiovascular disease plus 30 healthy controls
Comparison
Type 1 diabetic patients with cardiovascular disease vs without cardiovascular disease vs healthy controls
Design
Cross-sectional study
Authors
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Hyperglycemia-linked VCAM-1 rise may mark endothelial injury in T1DM; leaves open whether it drives premature atherosclerosis.
Cross-Sectional (n=90)
No
VCAM-1 levels are significantly elevated in pediatric and adolescent patients with Type 1 Diabetes Mellitus, suggesting its potential utility as a biomarker for endothelial dysfunction and future cardiovascular risk.
Saterr et al. (2021) conducted a cross-sectional in Type 1 Diabetes Mellitus (n=90). Type 1 Diabetes Mellitus vs. Healthy controls was evaluated on Serum VCAM-1 levels. Serum VCAM-1 levels were significantly higher in type 1 diabetes mellitus patients, both with and without cardiovascular disease, compared to healthy controls.
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