February 1, 1996British Journal of Haematology
Elevated plasma levels of vascular cell adhesion molecule‐1 (VCAM‐1) in diabetic patients with microalbuminuria: a marker of vascular dysfunction and progressive vascular disease
Why the study?
Do diabetic patients with microalbuminuria have higher plasma levels of sVCAM-1 compared to those without microalbuminuria?
Population
Diabetic patients with microalbuminuria
Design
Cross-sectional
Authors
Discussion
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Member takes
Implication
Hypothesis-generating for sVCAM-1 as vasculopathy biomarker in diabetes; prospective studies needed before clinical adoption.
Structured PICO
Do diabetic patients with microalbuminuria have higher plasma levels of sVCAM-1 compared to those without microalbuminuria?
P
Population
Diabetic patients with microalbuminuria
C
Comparator
Diabetic patients without microalbuminuria
O
Outcome
Plasma levels of soluble vascular cell adhesion molecule-1 (sVCAM-1)surrogate
Plasma sVCAM-1 is elevated in diabetic patients with microalbuminuria, suggesting it may serve as a biomarker for early vascular dysfunction and diabetic vasculopathy.
Cite This Study
Schmidt et al. (1996) studied this question.