January 1, 2001Journal of Atherosclerosis and ThrombosisOpen Access

Plasma Levels of Soluble Vascular Adhesion Molecule-1 and Cholesterol Oxidation Product in Type 2 Diabetic Patients with Nephropathy

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Population

31 patients with type 2 diabetes mellitus and 8 age-matched healthy controls.

Design

Cross-sectional

Authors

HMHiroshi MurakamiHiroshima University NTNaoki TamasawaInstitute for Advanced Study JMJun MatsuiCentral Research Institute of Electric Power Industry

Discussion

Member takes

Implication

VCAM-1 may mark oxidative vascular injury in diabetes; cross-sectional data leave causality and clinical utility open.

Structured PICO

Population

31 patients with type 2 diabetes mellitus (including 8 with macroalbuminuria and 15 with normoalbuminuria) and 8 age-matched healthy controls.

Comparator

Age-matched healthy controls (n=8) and normoalbuminuric diabetic patients (n=15)

Outcome

Plasma levels of soluble VCAM-1 and 7-ketocholesterolsurrogate

Soluble VCAM-1 is elevated in type 2 diabetes with nephropathy and correlates with cholesterol oxidation products, suggesting it may serve as a marker of oxidative stress and vascular injury.

Cite This Study

Murakami et al. (2001) studied this question.

synapsesocial.com/papers/6a7d3ba43575152c8237d8e7 https://doi.org/10.5551/jat1994.8.21

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Plasma Levels of Soluble Vascular Adhesion Molecule-1 and Cholesterol Oxidation Product in Type 2 Diabetic Patients with Nephropathy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Plasma Levels of Soluble Vascular Adhesion Molecule-1 and Cholesterol Oxidation Product in Type 2 Diabetic Patients with Nephropathy

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider