Key result
Intravenous terbutaline dose-dependently decreased parasympathetic cardiovascular reactivity and baroreflex sensitivity while increasing sympathetic dominance and heart rate regularity.
Why the study?
Does intravenous terbutaline alter heart rate and blood pressure variability and autonomic regulation in healthy adult volunteers?
RCT (n=6)
Placebo-controlled
Crossover
Does intravenous terbutaline alter heart rate and blood pressure variability and autonomic regulation in healthy adult volunteers?
Terbutaline infusion dose-dependently alters cardiovascular autonomic balance by increasing sympathetic dominance and decreasing parasympathetic reactivity.
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Alerts clinicians to autonomic effects with terbutaline use; extends RCT evidence of dose-dependent beta-agonist modulation in humans.
Jartti et al. (1998) conducted an RCT in Healthy volunteers (n=6). Intravenous terbutaline vs. Placebo was evaluated on Cardiovascular and respiratory autonomic nervous regulation (variability, approximate entropy, and fractal dimension of heart rate and blood pressure). Intravenous terbutaline dose-dependently decreased parasympathetic cardiovascular reactivity and baroreflex sensitivity while increasing sympathetic dominance and heart rate regularity.
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