Whole-heart computer modeling can successfully simulate clinical electrophysiological studies, including pacing protocols and mapping of accessory pathways.
Supports feasibility of in silico EPS simulation in WPW; leaves open human validation before clinical use.
We present a computer simulation of Electrophysiological Study (EPS) using a heart model. In this simulation, standard pacing protocols as used in the clinical EPS, including the atrial extrastimulation, ventricular extrastimulation, incremental atrial pacing, and incremental ventricular pacing, were developed in the heart model. The corresponding excitation and propagation process of the heart, and the intracardiac electrograms that would be measured with catheter electrodes were computed. We successfully reproduced the EPS tests with the heart model. Typical results included the determination of the refractory period, induction and termination of supraventricular tachycardias, and the localization of accessory pathway by using the heart model of the Wolff-Parkinson-White (WPW) syndrome of type A. We believe this study shows one of the latest progresses in application of whole-heart modeling and computer simulation of electrocardiology.
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Zhu et al. (2008) studied this question.
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