Key result
Computer simulation of clinical electrophysiological study successfully reproduced complicated cases including Wenckebach patterns and supraventricular tachycardia in Wolff-Parkinson-White syndrome.
Whole-heart computer modeling can successfully simulate clinical electrophysiological studies, including complex arrhythmias like WPW syndrome.
Provides proof-of-concept for arrhythmia simulation; leaves open human validation before clinical use.
BACKGROUND: Computer simulation is an important method for the basic researches of cardiac electrophysiology to prove the mechanisms and hypotheses of cardiac arrhythmias by reproducing body surface electrocardiograms. In this research, we extend the researches of heart models to the computer simulation of clinical electrophysiological study (EPS) as a clinical application of heart models. METHOD: Through setting the standard EPS pacing protocols, including extrastimuli and incremental pacing in the heart models, we simulated the corresponding excitation propagations in the heart and the intracardiac electrograms that would be measured with catheter electrodes. RESULTS: Examples of complicated cases observed during EPS are reproduced in this research, including the induction of a Wenckebach pattern, the induction and termination of supraventricular tachycardia due to the reentry loop of antidromic atrioventricular reentrant tachycardia for the Wolff-Parkinson-White (WPW) syndrome (Type A), and the localization of an accessory pathway for the WPW syndrome (Type A). CONCLUSION: This study demonstrates an application of whole-heart modeling and computer simulation to clinical EPS.
No takes yet. Share an insight, caveat, or question.
Zhu et al. (2012) studied Cardiac arrhythmias and Wolff-Parkinson-White (WPW) syndrome. Computer simulation of clinical electrophysiological study (EPS) was evaluated on Reproduction of complicated cases observed during EPS. Computer simulation of clinical electrophysiological study successfully reproduced complicated cases including Wenckebach patterns and supraventricular tachycardia in Wolff-Parkinson-White syndrome.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: