Key result
High ventilatory response to exercise (RR 3.20; 95% CI 1.95-5.26; P<0.0001) and low chronotropic index independently predicted mortality in heart failure patients over 1.5 years.
Cohort (n=487)
Effect estimate: RR 3.20 (95% CI 1.95 to 5.26)
p-value: p=<0.0001
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May refine heart failure risk stratification via exercise testing; leaves open whether targeting these parameters improves outcomes.
Robbins et al. (1999) conducted a cohort in Heart failure (n=487). High ventilatory response (V̇e/V̇co2) and low chronotropic index vs. Normal/lower ventilatory response and normal/higher chronotropic index was evaluated on Death (RR 3.20, 95% CI 1.95 to 5.26, p=<0.0001). High ventilatory response to exercise (RR 3.20; 95% CI 1.95-5.26; P<0.0001) and low chronotropic index independently predicted mortality in heart failure patients over 1.5 years.
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