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January 1, 2003Japanese Heart JournalOpen Access

Relationship Between Impaired Chronotropic Response, Cardiac Output During Exercise, and Exercise Tolerance in Patients with Chronic Heart Failure

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Population

24 patients with chronic heart failure and mild chronotropic incompetence, mean age 60.1 +/- 14.0 years.

Design

Cross-sectional

Authors

HSHisanori SamejimaToho UniversityKOKazuto OmiyaHeart Failure & TransplantMUMasato UnoSt. Marianna University School of Medicine

Discussion

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Implication

May underlie exercise intolerance in chronic HF; hypothesis-generating for sympathetic chronotropic modulation.

Structured PICO

P
Population
24 patients with chronic heart failure and mild chronotropic incompetence, mean age 60.1 +/- 14.0 years.
O
Outcome
Correlation between deltaHR/log deltaNE and exercise tolerance parameters (anaerobic threshold, peak VO2, VE/VCO2 slope) and cardiac output parameters.surrogate

In patients with chronic heart failure, impaired chronotropic response to sympathetic stimulation contributes to inadequate cardiac output and reduced exercise tolerance.

Cite This Study

Samejima et al. (2003) studied this question.

synapsesocial.com/papers/6a8ceaef42b2f342f8279326https://doi.org/10.1536/jhj.44.515

Topics

Heart failureHFrEF treatment
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Decreased Catecholamine Sensitivity and β-Adrenergic-Receptor Density in Failing Human Hearts1982 · 2,283 citations
  2. 2The role of the exercise test in the evaluation of patients for ischemic heart disease.1978 · 499 citations
  3. 3Slow Heart Rates and Increased Risk of Cardiac Death in Middle-Aged Men1972 · 142 citations
  4. 4Ventilatory and Heart Rate Responses to Exercise1999 · 222 citations
  5. 5Chronotropic incompetence in exercise testing1979 · 82 citations