What does this research mean for the field?

The clinical utility of prostate specific antigen (PSA) in managing prostate disease has been enhanced by a better understanding of its biochemistry and the standardization of commercial assays to the WHO International Standard. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To review the biology and complex biochemistry of prostate specific antigen (PSA) and assess commercial diagnostic assays available for clinical prostate disease management.

November 1, 2001Annals of Clinical Biochemistry International Journal of Laboratory Medicine

Prostate specific antigen: biology, biochemistry and available commercial assays

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Authors

AWA. Milford WardUniversity of Tennessee Medical Center JCJames W.F. CattoThiel College FHFreddie C. HamdyUniversité Claude Bernard Lyon 1

Discussion

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Implication

Review summarizes prostate specific antigen assay performance in prostate disease management, indicating improved diagnostic conformity following international standardization.

Key Points

To review the biology and complex biochemistry of prostate specific antigen (PSA) and assess commercial diagnostic assays available for clinical prostate disease management.
Reviewed serum PSA biochemistry, including five known isoforms and molecular complex configurations.
Evaluated commercial PSA assay platforms available in the UK, focusing on calibration against the World Health Organization 1st International Standard (90:10).
Analyzed diagnostic performance assessments conducted on behalf of the Medical Devices Agency of the UK Department of Health.
Circulating PSA exists in multiple configurations and five distinct isoforms, which enhances its diagnostic capability in distinguishing prostate malignancy.
Adoption of the WHO 1st International Standard (90:10) for assay calibration markedly improved measurement conformity across commercial testing platforms.
Regulatory and clinical evaluations led to the widespread withdrawal or replacement of older non-equimolar assay kits.

Cite This Study

Ward et al. (2001) studied this question.

synapsesocial.com/papers/6a0e35ff1d0a44496ac83480 https://doi.org/10.1258/0004563011901055

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Implication

Review summarizes prostate specific antigen assay performance in prostate disease management, indicating improved diagnostic conformity following international standardization.

Prostate specific antigen: biology, biochemistry and available commercial assays

Discussion

Member takes

Implication

Key Points

Cite This Study

Prostate specific antigen: biology, biochemistry and available commercial assays

Discussion

Member takes

Implication

Key Points

Cite This Study

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