What question did this study set out to answer?

To identify, purify, and characterize a novel prostate-specific antigen and assess its potential as a serum biomarker for prostate cancer.

January 1, 1981The Prostate

Prostate antigen: A new potential marker for prostatic cancer

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Laboratory study reveals elevated prostate-specific antigen levels in prostate cancer serum, indicating its utility as a diagnostic marker.

To identify, purify, and characterize a novel prostate-specific antigen and assess its potential as a serum biomarker for prostate cancer.
Purified the antigen from human prostate tissues and seminal plasma, determining its molecular weight and isoelectric point.
Localized the antigen in normal, benign hypertrophic, and malignant prostate tissues using immunoperoxidase staining.
Developed a sandwich-type peroxidase-linked immunosorbent assay with a sensitivity of 0.1 ng/mL to quantify serum antigen levels.
Purified prostate tissue antigen presented as a single-chain molecule with a molecular weight of 33,000–34,000 and an isoelectric point near 6.9, localized specifically to ductal epithelial cells.
Serum-borne antigen exhibited a native molecular weight of 90,000–100,000, which dissociated to 36,000 under sodium dodecyl sulfate conditions.
Serum antigen concentrations were elevated in patients with prostatic cancer compared to normal male controls.

Wang et al. (1981) studied this question.

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Laboratory study reveals elevated prostate-specific antigen levels in prostate cancer serum, indicating its utility as a diagnostic marker.