Each 5-mm Hg increment in exercise systolic or diastolic blood pressure was independently associated with an 11% and 30% increased risk for developing hypertension, respectively (P<0.001).
Cohort (n=7,082)
No
Effect estimate: 11% increased risk per 5-mmHg SBP increment
Absolute Event Rate: 35% vs 5%
p-value: p=<0.001
BACKGROUND: The aim of the present study was to examine whether exercise blood pressure can be used to predict the development of hypertension in normotensive middle-aged adults. METHODS AND RESULTS: We investigated 7082 normotensive subjects who were annually screened in a tertiary medical center and completed maximal treadmill exercise tests at each visit. After the initial 3 years, subjects were divided into approximate quartiles according to their average exercise systolic and diastolic blood pressure responses (≤158; 158 to 170; 170 to 183; ≥183 mm Hg for systolic blood pressure and ≤73; 73 to 77; 77 to 82; ≥82 mm Hg for diastolic blood pressure). Mean age of the study population was 48 ± 9 years and 73% were men. Average baseline resting blood pressure was 120/77 ± 12/7 mm Hg. During a follow-up of 5 ± 3 years, 1036 (14.6%) subjects developed hypertension. The cumulative probability of new-onset hypertension at 5 years was significantly increased with increasing quartiles of exercise systolic blood pressure (5%, 9%, 17%, and 35%, respectively; P<0.001), with a similar association shown for diastolic blood pressure. After adjustment for baseline resting blood pressure and clinical parameters, each 5-mm Hg increments in exercise either systolic or diastolic blood pressures were independently associated with respective 11% (P<0.001) and 30% (P<0.001) increased risk for the development of hypertension. CONCLUSIONS: In normotensive middle-aged individuals, blood pressure response to exercise is associated with future development of hypertension.
Berger et al. (Wed,) conducted a cohort in Normotension (n=7,082). Exercise blood pressure response vs. Lower quartiles of exercise blood pressure was evaluated on New-onset hypertension (11% increased risk per 5-mmHg SBP increment, p=<0.001). Each 5-mm Hg increment in exercise systolic or diastolic blood pressure was independently associated with an 11% and 30% increased risk for developing hypertension, respectively (P<0.001).