Key result
Exercise on a treadmill for 11 weeks increased cardiac dilatation (1.41 vs 1.20 ml/kg at 8 mmHg, p<0.005) and augmented cellular and humoral autoimmunity in experimental autoimmune myocarditis.
Why the study?
Does exercise augment cardiac dilatation and autoimmunity in guinea pigs with experimental autoimmune myocarditis?
Population
Guinea pigs immunised with heterologous heart protein, Freund's complete adjuvant, and pertussis vaccine to…
Comparison
Treadmill exercise for a total of 11 weeks vs No exercise (non-exercise treated animals)
Design
Preclinical
Follow-up
11 weeks
Authors
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Hypothesis-generating in guinea pig myocarditis models; leaves open translation to human exercise guidance.
Does exercise augment cardiac dilatation and autoimmunity in guinea pigs with experimental autoimmune myocarditis?
Absolute Event Rate: 1.41% vs 1.2%
p-value: p=<0.005
In a guinea pig model of experimental autoimmune myocarditis, exercise exacerbates cardiac dilatation and autoimmunity, although this does not correlate with the degree of histological inflammation.
Hosenpud et al. (1987) studied Experimental autoimmune myocarditis. Exercise on a treadmill vs. Non-exercise was evaluated on Cardiac dilatation assessed by in vitro left ventricular pressure-volume relations at 8 mmHg (ml.kg-1) (p=<0.005). Exercise on a treadmill for 11 weeks increased cardiac dilatation (1.41 vs 1.20 ml/kg at 8 mmHg, p<0.005) and augmented cellular and humoral autoimmunity in experimental autoimmune myocarditis.