August 1, 1994Circulation Research

Rat dilated cardiomyopathy after autoimmune giant cell myocarditis.

View Full Paper

Ask AI

Bookmark

Why the study?

Does immunization with cardiac myosin fraction induce dilated cardiomyopathy in Lewis rats?

Population

Lewis rats

Comparison

Immunization with cardiac myosin fraction to… vs Immunization with ovalbumin

Design

Preclinical

Follow-up

4 months

Authors

MKMakoto KodamaKanazawa University HHHaruo HanawaNiigata University of Health and Welfare MSMakihiko SaekiNagaoka University

Discussion

Member takes

Implication

Supports autoimmune myocarditis progressing to dilated cardiomyopathy in rats; hypothesis-generating for human translation.

Structured PICO

Does immunization with cardiac myosin fraction induce dilated cardiomyopathy in Lewis rats?

Population

Lewis rats

Intervention

Immunization with cardiac myosin fraction to elicit experimental autoimmune myocarditis

Comparator

Immunization with ovalbumin

Outcome

Development of dilated cardiomyopathy (assessed by heart weight to body weight ratio, heart dimensions, and histological findings)surrogate

This preclinical study demonstrates that autoimmune myocarditis, independent of viral infection, can progress to dilated cardiomyopathy in a rat model.

Cite This Study

Kodama et al. (1994) studied this question.

synapsesocial.com/papers/6a712bafc2d7c309082704ea https://doi.org/10.1161/01.res.75.2.278

Topics

Myocarditis

View Full Paper

Ask AI

Bookmark

Rat dilated cardiomyopathy after autoimmune giant cell myocarditis.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Rat dilated cardiomyopathy after autoimmune giant cell myocarditis.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider