Key result
Cardiac myosin immunization triggers T-cell-mediated autoimmune giant cell myocarditis and heart failure in rats.
Why the study?
The study was conducted to identify a cardiac protein capable of causing serious autoimmune myocarditis.
Does cardiac myosin immunization induce autoimmune giant cell myocarditis in animal models?
Does cardiac myosin immunization induce autoimmune giant cell myocarditis in animal models?
Cardiac myosin immunization establishes a robust experimental model of autoimmune giant cell myocarditis in Lewis rats, mediated by T-lymphocytes.
Offers reproducible rat model for T-cell myocarditis research; leaves open human translation and therapies.
To identify a cardiac protein that could cause a serious autoimmune myocarditis, membranous proteins and myosin as antigens were investigated. In mice immunized with membranous proteins, the lesions induced were limited on the histological level. On the other hand, in Lewis rats immunized with cardiac myosin, serious myocarditis was induced. Every rat showed evidence of heart failure which was fatal in a few. Histology disclosed extensive cell infiltrates and myocardial necrosis. Among those lesions, giant cells were present. This myocarditis could be also transferred adoptively by lectin-activated spleen cells, T-lymphocytes, but not by IgG fraction. Thus, cardiac myosin can induce autoimmune giant cell myocarditis in Lewis rats.
No takes yet. Share an insight, caveat, or question.
Izumi et al. (1991) studied Autoimmune giant cell myocarditis. Cardiac myosin immunization vs. Membranous proteins immunization was evaluated on Induction of myocarditis. Immunization with cardiac myosin induced serious autoimmune giant cell myocarditis and heart failure in Lewis rats, which could be adoptively transferred by T-lymphocytes.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: