Key result
Sublingual nifedipine prevented the increase in coronary resistance induced by the cold pressor test (0.76 vs 1.17 mm Hg/ml/min) and increased coronary blood flow during isometric exercise.
Why the study?
Does sublingual nifedipine improve coronary blood flow and resistance during cold pressor test and isometric exercise in patients with coronary artery disease?
Population
8 patients with coronary artery disease
Comparison
Sublingual administration of nifedipine vs Baseline (before nifedipine administration)
Design
Other
Follow-up
20 minutes
Authors
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Hypothesis-generating for sublingual nifedipine in CAD cold pressor response; prospective trials needed before clinical adoption.
Does sublingual nifedipine improve coronary blood flow and resistance during cold pressor test and isometric exercise in patients with coronary artery disease?
Absolute Event Rate: 0.76% vs 1.17%
Sublingual nifedipine prevents cold-induced coronary vasoconstriction and improves coronary blood flow during isometric exercise in patients with coronary artery disease.
Servi et al. (1980) studied coronary artery disease (n=8). nifedipine vs. baseline (before nifedipine) was evaluated on coronary resistance during cold pressor test (mm Hg/ml/min). Sublingual nifedipine prevented the increase in coronary resistance induced by the cold pressor test (0.76 vs 1.17 mm Hg/ml/min) and increased coronary blood flow during isometric exercise.