Key result
High-dose PEG-SOD (1 x 10^5 U/kg/d) reduced survival in mice with CB3 myocarditis compared to controls (40% vs 78%, p<0.01), whereas lower doses improved cardiac pathology.
Why the study?
Does polyethylene glycol conjugated superoxide dismutase improve survival and cardiac pathology in a mouse model of coxsackievirus B3 myocarditis?
Population
Two week old male C3H/He mice inoculated intraperitoneally with 10^3 plaque forming units of coxsackievirus B3
Comparison
Polyethylene glycol conjugated superoxide… vs Infected control group
Design
Preclinical
Follow-up
14 days
Authors
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High-dose PEG-SOD may impair survival in viral myocarditis models; leaves open optimal dosing for antioxidant therapy in cardiac inflammation.
Does polyethylene glycol conjugated superoxide dismutase improve survival and cardiac pathology in a mouse model of coxsackievirus B3 myocarditis?
Absolute Event Rate: 40% vs 78%
p-value: p=< 0.01
Appropriate low doses of PEG-SOD improve cardiac pathology in coxsackievirus B3 myocarditis by inhibiting oxygen free radicals, but high doses can impair survival and worsen pathology.
Hiraoka et al. (1992) studied coxsackievirus B3 (CB3) myocarditis. polyethylene glycol conjugated superoxide dismutase (PEG-SOD) vs. infected control was evaluated on survival rate (p=< 0.01). High-dose PEG-SOD (1 x 10^5 U/kg/d) reduced survival in mice with CB3 myocarditis compared to controls (40% vs 78%, p<0.01), whereas lower doses improved cardiac pathology.
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