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June 1, 1993Cardiovascular Research

Role of oxygen derived free radicals in the pathogenesis of coxsackievirus B3 myocarditis in mice

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Why the study?

Does PEG-SOD alone or in combination with PEG-catalase reduce myocardial injury in a mouse model of coxsackievirus B3 myocarditis?

Population

Two week old male C3H/He mice inoculated intraperitoneally with 10^3 plaque forming units of coxsackievirus B3

Comparison

Polyethylene glycol conjugated superoxide… vs Infected control

Design

Preclinical

Follow-up

14 days

Authors

YHYuji HiraokaJichi Medical UniversityCKC. KishimotoTohoku Medical and Pharmaceutical UniversityHTHitoshi TakadaObayashi (Japan)

Discussion

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Member takes

Implication

Supports superoxide scavenging in murine viral myocarditis; leaves open translation to human disease.

Structured PICO

Does PEG-SOD alone or in combination with PEG-catalase reduce myocardial injury in a mouse model of coxsackievirus B3 myocarditis?

P
Population
Two week old male C3H/He mice inoculated intraperitoneally with 10^3 plaque forming units of coxsackievirus B3 (CB3)
I
Intervention
Polyethylene glycol conjugated superoxide dismutase (PEG-SOD) 1 x 10^3 U.kg-1 x d-1 alone, or PEG-SOD 1 x 10^3 U.kg-1 x d-1 plus polyethylene glycol conjugated catalase (PEG-catalase) 1 x 10^3 U.kg-1 x d-1, injected subcutaneously daily on days 0 to 14
C
Comparator
Infected control
O
Outcome
Pathological scores (cellular infiltration, myocardial necrosis, and calcification) and myocardial virus titres on days 7 and 14surrogate

In a mouse model of coxsackievirus B3 myocarditis, administration of PEG-SOD significantly reduced myocardial injury, suggesting superoxide anion plays a key role in free radical-mediated myocyte injury.

Cite This Study

Hiraoka et al. (1993) studied this question.

synapsesocial.com/papers/6a840025e7eedc1abc68ba2bhttps://doi.org/10.1093/cvr/27.6.957

Topics

Myocarditis
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Effects of polyethylene glycol conjugated superoxide dismutase on coxsackievirus B3 myocarditis in mice1992 · 36 citations
  2. 2Enhanced expression of superoxide dismutase messenger RNA in viral myocarditis. An SH-dependent reduction of its expression and myocardial injury.1993 · 58 citations
  3. 3The role of CD8+ T lymphocytes in coxsackievirus B3-induced myocarditis1995 · 264 citations
  4. 4Role of superoxide anion in the pathogenesis of cytokine-induced myocardial dysfunction in dogs in vivo1999 · 44 citations
  5. 5Mouse Strain-related Variation as a Factor in the Pathogenesis of Coxsackievirus B3 Murine Myocarditis1987 · 24 citations