Key result
Immunosuppressants yield highly variable responses across genetic strains in murine viral myocarditis, suggesting distinct pathomechanisms.
Why the study?
The effects of various immunosuppressive agents on coxsackievirus B3-induced myocarditis in genetically different mouse strains were not well understood.
The response to immunosuppressive therapy in viral myocarditis is highly dependent on genetic background, suggesting diverse underlying immune pathomechanisms.
Answers are grounded in this paper and cite their sources.
Variable responses to immunosuppression in murine viral myocarditis models warrant caution against uniform human application; leaves open distinct pathomechanisms across genetic backgrounds.
Using the murine model of coxsackievirus B3-induced myocarditis we studied the effects of various immunosuppressive agents on the course and outcome of the disease in genetically different strains of mice. The response to drug treatment varied greatly among the strains of inbred mice, which suggests different immune pathomechanisms operative in mediating myocarditis.
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Herzum et al. (1991) studied this question. Immunosuppressive agents yielded highly variable responses across genetically different mouse strains with coxsackievirus B3-induced myocarditis, suggesting distinct immune pathomechanisms.
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