A proposed shear-dependent computational model successfully simulated platelet aggregation and thrombus formation across a wide range of flow shear rates from 100 to 28,000 s-1.
A novel computational model accurately simulates shear-dependent platelet adhesion and coagulation across diverse hemodynamic conditions, from venous to high-shear arterial thrombosis.
Modeling the transport, activation, and adhesion of platelets is crucial in predicting thrombus formation and growth following a thrombotic event in normal or pathological conditions. We propose a shear-dependent platelet adhesive model based on the Morse potential that is calibrated by existing in vivo and in vitro experimental data and can be used over a wide range of flow shear rates (Formula: see text). We introduce an Eulerian-Lagrangian model where hemodynamics is solved on a fixed Eulerian grid, while platelets are tracked using a Lagrangian framework. A force coupling method is introduced for bidirectional coupling of platelet motion with blood flow. Further, we couple the calibrated platelet aggregation model with a tissue-factor/contact pathway coagulation cascade, representing the relevant biology of thrombin generation and the subsequent fibrin deposition. The range of shear rates covered by the proposed model encompass venous and arterial thrombosis, ranging from low-shear-rate conditions in abdominal aortic aneurysms and thoracic aortic dissections to thrombosis in stenotic arteries following plaque rupture, where local shear rates are extremely high.
Yazdani et al. (Tue,) conducted a other in Thrombus formation. Shear-dependent Eulerian-Lagrangian computational model was evaluated. A proposed shear-dependent computational model successfully simulated platelet aggregation and thrombus formation across a wide range of flow shear rates from 100 to 28,000 s-1.
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