Key result
A novel combined ex vivo and in silico methodology successfully quantified the Lagrangian shear rate experienced by individual platelets, revealing that high shear gradients contribute significantly to regions of high thrombus growth.
A novel combined ex vivo and in silico methodology enables real-time measurement of flow-induced shear rates experienced by individual platelets during thrombus formation.
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Advances platelet shear modeling; leaves open in vivo validation before clinical thrombosis applications.
Pinar et al. (2015) studied Thrombus formation (n=2). Combined ex vivo and in silico methodology was evaluated on Correlation of Lagrangian flow properties with subsequent thrombus growth. A novel combined ex vivo and in silico methodology successfully quantified the Lagrangian shear rate experienced by individual platelets, revealing that high shear gradients contribute significantly to regions of high thrombus growth.
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