Key result
Genetic analysis of a family with short QT syndrome and paroxysmal atrial fibrillation identified the N588K missense mutation in KCNH2, and treatment with propafenone prevented AF episodes.
Population
A family with short QT syndrome characterized by a high incidence of paroxysmal atrial fibrillation and no…
Design
Case_series
Authors
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May support propafenone for AF in N588K short QT families; leaves open confirmation in prospective studies.
Observational
The N588K mutation in KCNH2 is a hotspot for familial short QT syndrome, which can present with paroxysmal atrial fibrillation that may be responsive to propafenone.
Hong et al. (2005) conducted an observational in Short QT syndrome and atrial fibrillation. Propafenone was evaluated on Genetic mutation identification and clinical characteristics. Genetic analysis of a family with short QT syndrome and paroxysmal atrial fibrillation identified the N588K missense mutation in KCNH2, and treatment with propafenone prevented AF episodes.
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