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January 1, 2009Journal of Cardiovascular Magnetic ResonanceOpen Access

Validation of cardiovascular magnetic resonance assessment of pericardial adipose tissue volume

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Key result

Cardiovascular magnetic resonance-derived paracardial adipose tissue volume strongly correlated with ex vivo paracardial mass (R2 = 0.89, p < 0.001) in an ovine model.

Why the study?

Does cardiovascular magnetic resonance accurately measure pericardial adipose tissue volume compared to ex vivo mass in an ovine model?

Population

11 merino sheep (49 ± 7 kg) in an ovine model.

Comparison

Cardiovascular magnetic resonance assessment of… vs Ex vivo paracardial adipose tissue mass measured…

Design

Preclinical

Authors

ANAdam J. NelsonMWM. WorthleyPPPeter J. Psaltis

Discussion

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Overview

Supports CMR paracardial fat quantification in preclinical models; leaves open human translation and outcome links.

Structured PICO

Does cardiovascular magnetic resonance accurately measure pericardial adipose tissue volume compared to ex vivo mass in an ovine model?

P
Population
11 merino sheep (49 ± 7 kg) in an ovine model.
I
Intervention
Cardiovascular magnetic resonance (CMR) assessment of paracardial adipose tissue volume using standard clinical series of ventricular short axis images (1.5T Siemens Sonata).
C
Comparator
Ex vivo paracardial adipose tissue mass measured at necropsy, and CMR measurement of right ventricular free wall paracardial adipose thickness.
O
Outcome
Correlation between CMR-derived paracardial adipose tissue volume and ex vivo paracardial mass.surrogate

Main Result

Effect estimate: R2 = 0.89

p-value: p=<0.001

CMR-derived paracardial adipose tissue volume accurately reflects ex vivo paracardial adipose tissue mass in an ovine model, validating standard CMR sequences for assessing pericardial adiposity.

Limitations

  • Study was performed in an animal model rather than humans
  • Did not use pre-defined, fat-specific imaging sequences
  • CMR protocol did not utilize inter-slice gaps in the short axis stack
  • Performed in an animal model
  • Impossible to accurately dissect epicardial adipose tissue from the myocardium, preventing correlation of the epicardial component

Cite This Study

Nelson et al. (2009) studied Pericardial adipose tissue assessment (n=11). Cardiovascular magnetic resonance (CMR) vs. Ex vivo paracardial mass at necropsy was evaluated on Correlation between CMR-derived paracardial adipose tissue volume and ex vivo paracardial mass (R2 = 0.89, p=<0.001). Cardiovascular magnetic resonance-derived paracardial adipose tissue volume strongly correlated with ex vivo paracardial mass (R2 = 0.89, p < 0.001) in an ovine model.

synapsesocial.com/papers/6a0e4e6cbc348c84f2fd9ad3https://doi.org/10.1186/1532-429x-11-15
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Volumetric Assessment of Epicardial Adipose Tissue With Cardiovascular Magnetic Resonance Imaging2007 · 212 citations
  2. 2Relationship of epicardial adipose tissue by echocardiography to coronary artery disease2007 · 324 citations
  3. 3Epicardial adipose tissue imaged by magnetic resonance imaging: an important risk marker of cardiovascular disease2006 · 30 citations
  4. 4Pericardial Fat, Intrathoracic Fat, and Measures of Left Ventricular Structure and Function2009 · 248 citations