Key result
Non-insulin dependent diabetes mellitus is associated with significantly higher total interstitial myocardial fibrosis (p<0.05), primarily driven by an increase in collagen type III (p<0.01).
Population
18 patients undergoing myocardial biopsy, with no history of hypertension or coronary artery stenosis.
Design
Case-control
Authors
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Diabetes may promote specific myocardial fibrosis; leaves open impact on outcomes and therapy.
Case-Control (n=18)
p-value: p=<0.05
Patients with diabetes exhibit increased myocardial interstitial fibrosis, primarily due to an accumulation of type III collagen, independent of hypertension or coronary artery disease.
Shimizu et al. (1993) conducted a case-control in Non-insulin dependent diabetes mellitus (n=18). Non-insulin dependent diabetes mellitus (exposure) vs. Non-diabetic controls was evaluated on Percentage of total interstitial fibrosis in the myocardium (p=<0.05). Non-insulin dependent diabetes mellitus is associated with significantly higher total interstitial myocardial fibrosis (p<0.05), primarily driven by an increase in collagen type III (p<0.01).
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