Key result
In patients with hypertrophic cardiomyopathy, the progression of myocardial interstitial fibrosis and increases in type III and VI collagen correlated significantly with cardiac dysfunction.
Why the study?
Does the extent and specific type of myocardial interstitial collagen correlate with left ventricular dysfunction in patients with hypertrophic cardiomyopathy?
Population
35 patients with hypertrophic cardiomyopathy (HC) undergoing myocardial biopsy
Design
Cross-sectional
Authors
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Associates type III/VI collagen with HCM dysfunction; hypothesis-generating and should not yet change practice.
Observational (n=35)
Does the extent and specific type of myocardial interstitial collagen correlate with left ventricular dysfunction in patients with hypertrophic cardiomyopathy?
In patients with hypertrophic cardiomyopathy, the accumulation of specific collagen types (III and VI) in the myocardial interstitium is significantly associated with both systolic and diastolic left ventricular dysfunction.
Kitamura et al. (2001) conducted an observational in Hypertrophic cardiomyopathy (n=35). Myocardial interstitial fibrosis and collagen types was evaluated on Correlation of myocardial interstitial fibrosis and collagen types with LV diastolic and systolic function. In patients with hypertrophic cardiomyopathy, the progression of myocardial interstitial fibrosis and increases in type III and VI collagen correlated significantly with cardiac dysfunction.
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