Key result
Age under 60 in STEMI is linked to ~251% higher risk of adverse ventricular remodeling.
Why the study?
Young STEMI patients display a unique risk profile compared with older patients, but whether these differences are related to disparities in ventricular remodeling remains unknown.
Does younger age (<60 years) increase the risk of adverse ventricular remodeling in STEMI patients undergoing primary percutaneous coronary intervention?
Observational (n=123)
Does younger age (<60 years) increase the risk of adverse ventricular remodeling in STEMI patients undergoing primary percutaneous coronary intervention?
Younger patients (<60 years) with STEMI undergoing PPCI are at a higher risk of adverse ventricular remodeling and less likely to develop reverse remodeling compared to older patients.
Younger STEMI patients may need closer remodeling surveillance; this cohort finding leaves open age-specific interventions.
Objectives Young patients account for about half of ST-segment elevation myocardial infarction (STEMI) patients and display a unique risk profile compared with old patients. Whether these differences are related to disparities in ventricular remodeling remains unknown. This study aimed to evaluate age-related differences in ventricular remodeling after primary percutaneous coronary intervention (PPCI) for STEMI. Methods In this observational study, consecutive STEMI patients between October 2019 and March 2021 who underwent serial cardiovascular magnetic resonance at index admission (3 to 7 days) and 3 months after PPCI were enrolled. Adverse remodeling was defined as ≥ 10% enlargement in left ventricular end-diastolic volume index (LVEDVi), while reverse remodeling was defined as a decrease in left ventricular end-systolic volume index (LVESVi) of more than 10%. Results A total of 123 patients were included and grouped into young (< 60 years, n = 71) and old (≥ 60 years, n = 52) patients. Despite generally similar baseline structural and infarct characteristics, LVESVi significantly decreased only in old patients during follow-up ( p = 0.034). The incidence of adverse remodeling was higher (49.3% vs 30.8%, p = 0.039), while the incidence of reverse remodeling was lower (31.0% vs 53.8%, p = 0.011) in young compared with old patients. Younger age (< 60 years) was associated with a significantly higher risk of adverse remodeling (adjusted OR 3.51, 95% CI 1.41–8.74, p = 0.007) and lower incidence of reverse remodeling (adjusted OR 0.42, 95% CI 0.18–0.97, p = 0.046). Conclusions In STEMI patients undergoing PPCI, young patients are at a higher risk of adverse remodeling and less probably develop reverse remodeling than old patients. Equal or more attention should be paid to young patients with STEMI compared with their older counterparts. Key Points • In STEMI patients undergoing PPCI, young patients displayed unfavorable remodeling compared with old patients . • Young patients are at a higher risk of adverse remodeling and less probably develop reverse remodeling than old patients . • Equal or more attention should be paid to young patients compared with their older counterparts .
No takes yet. Share an insight, caveat, or question.
Guo et al. (2023) conducted an observational in ST-segment elevation myocardial infarction (STEMI) (n=123). Younger age (< 60 years) vs. Older age (≥ 60 years) was evaluated on Adverse remodeling (≥ 10% enlargement in left ventricular end-diastolic volume index) (adjusted OR 3.51, 95% CI 1.41-8.74, p=0.007). Younger age (< 60 years) in STEMI patients was associated with a significantly higher risk of adverse ventricular remodeling compared with older patients (adjusted OR 3.51; 95% CI 1.41-8.74; p=0.007).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: