Early IV diuresis (door-to-IV diuretic time 30-105 minutes) was associated with a 23% reduction in 30-day mortality in patients with acute heart failure (OR 0.77; 95% CI 0.64-0.93).
Meta-Analysis (n=28,124)
Does early intravenous diuresis (door-to-diuretic time 30-105 minutes) reduce mortality in patients with acute heart failure?
Early administration of intravenous diuretics (within 30-105 minutes of arrival) in acute heart failure is associated with a significant reduction in 30-day mortality.
Estimación del efecto: OR 0.77 (95% CI 0.64-0.93)
Early decongestion therapy with intravenous diuretics may be associated with improved outcomes in acute heart failure (AHF), however data is conflicting. This meta-analysis sought to evaluate the impact of door-to-IV diuretic (D2D) time on mortality in patients with AHF. Pooled estimates from observational studies comprising 28,124 patients, early IV diuresis (reference time 30-105 minutes) was associated with a 23% reduction in 30-day mortality in AHF (OR 0.77; 95% CI 0.64-0.93), despite no significant in-hospital death reduction (OR 0.84; 95% CI 0.57-1.24).
Rodrigues et al. (Tue,) conducted a meta-analysis in Acute heart failure (AHF) (n=28,124). Early IV diuresis (door-to-IV diuretic time 30-105 minutes) was evaluated on 30-day mortality (OR 0.77, 95% CI 0.64-0.93). Early IV diuresis (door-to-IV diuretic time 30-105 minutes) was associated with a 23% reduction in 30-day mortality in patients with acute heart failure (OR 0.77; 95% CI 0.64-0.93).