Key result
Prior aborted SCD or arrhythmic syncope with spontaneous type 1 ECG reliably predict Brugada arrhythmias.
This review highlights that a history of aborted sudden cardiac death or arrhythmic syncope, along with a spontaneous type 1 ECG pattern, are key predictors of arrhythmic events in Brugada syndrome.
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Supports risk stratification in Brugada syndrome; leaves open prospective validation before guiding ICD decisions.
The Brugada syndrome (BrS) is an arrhythmogenic disease associated with an increased risk of ventricular fibrillation and sudden cardiac death. The risk stratification and management of BrS patients, particularly of asymptomatic ones, still remains challenging. A previous history of aborted sudden cardiac death or arrhythmic syncope in the presence of spontaneous type 1 ECG pattern of BrS phenotype appear to be the most reliable predictors of future arrhythmic events. Several other ECG parameters have been proposed for risk stratification. Among these ECG markers, QRS-fragmentation appears very promising. Although the value of electrophysiological study still remains controversial, it appears to add important information on risk stratification, particularly when incorporated in multiparametric scores in combination with other known risk factors. The present review article provides an update on the pathophysiology, risk stratification and management of patients with BrS.
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Yoshifusa Aizawa (2016) conducted a review in Brugada syndrome. A previous history of aborted sudden cardiac death or arrhythmic syncope with a spontaneous type 1 ECG pattern are the most reliable predictors of future arrhythmic events in Brugada syndrome.
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