Key result
Echo-derived CFVR and GLS detect microvascular and subclinical LV dysfunction in women with INOCA.
Why the study?
The pathophysiological background of INOCA remains elusive, and subtle impairments of LV systolic function are difficult to assess by wall motion abnormalities.
What is the role of different echocardiographic modalities in assessing microvascular and left ventricular systolic function in women with INOCA?
What is the role of different echocardiographic modalities in assessing microvascular and left ventricular systolic function in women with INOCA?
Echocardiography, particularly using coronary flow velocity reserve and global longitudinal strain, provides important non-invasive assessment of microvascular and early systolic dysfunction in women with INOCA.
May support echocardiography for INOCA microvascular assessment; leaves open prospective validation before practice change.
This review summarizes current knowledge about echocardiographic modalities used to assess microvascular function and left ventricular (LV) systolic function in women with ischemia and no obstructive coronary arteries (INOCA). Although the entire pathophysiological background of this clinical entity still remains elusive, it is primarily linked to microvascular dysfunction which can be assessed by coronary flow velocity reserve. Subtle impairments of LV systolic function in women with INOCA are difficult to assess by interpretation of wall motion abnormalities. LV longitudinal function impairment is considered to be an early marker of subclinical systolic dysfunction and can be assessed by global longitudinal strain quantification.
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Jovanović et al. (2022) conducted a review in Ischemia and no obstructive coronary arteries (INOCA). Echocardiographic modalities (coronary flow velocity reserve, global longitudinal strain) was evaluated. Echocardiographic modalities, specifically coronary flow velocity reserve and global longitudinal strain, can assess microvascular and early subclinical LV systolic dysfunction in women with INOCA.
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