Why the study?
Although obstructive sleep apnea is associated with obesity and inflammation, the exact underlying mechanisms remain to be fully understood.
Are serum concentrations of IL-6 and TNF-alpha elevated in obese patients with obstructive sleep apnea compared to obese patients without OSA?
Population
Forty-six obese OSA patients and 42 obese non-OSA controls
Comparison
Obese OSA patients vs obese non-OSA subjects
Design
Case-control study
Key result
Obstructive sleep apnea in obese patients was not associated with significantly different serum levels of IL-6 (p=0.92) or TNF-α (p=0.09) compared to obese patients without obstructive sleep apnea.
Authors
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No OSA-related IL-6/TNF-α elevation in obesity; hypothesis-generating and requires prospective validation before clinical consideration.
Case-Control (n=88)
No
Are serum concentrations of IL-6 and TNF-alpha elevated in obese patients with obstructive sleep apnea compared to obese patients without OSA?
Absolute Event Rate: 10.65% vs 7.36%
p-value: p=0.09
In obese patients, the presence of obstructive sleep apnea was not associated with significantly higher serum levels of IL-6 and TNF-alpha compared to obese controls without OSA.
Minaeian et al. (2022) conducted a case-control in Obstructive Sleep Apnea in Obese Patients (n=88). Obstructive Sleep Apnea (OSA) vs. Non-OSA obese individuals was evaluated on Serum TNF-α levels (pg/mL) (p=0.09). Obstructive sleep apnea in obese patients was not associated with significantly different serum levels of IL-6 (p=0.92) or TNF-α (p=0.09) compared to obese patients without obstructive sleep apnea.