Key result
Severe OSAS increased IL-6 levels in males (p=0.005) but not females, while obesity independently increased both CRP (p=0.001) and IL-6 (p<0.001) levels regardless of OSAS severity and sex.
Why the study?
The interaction among OSAS severity, sex, and obesity on cardiovascular risk as determined by serum CRP, IL-6, and TNF-alpha remains unclear.
How do OSAS severity, sex, and obesity interact to affect circulatory inflammatory biomarkers in patients with suspected OSAS?
Cross-Sectional (n=100)
How do OSAS severity, sex, and obesity interact to affect circulatory inflammatory biomarkers in patients with suspected OSAS?
In patients with suspected OSAS, obesity independently increases CRP and IL-6, while OSAS severity increases IL-6 specifically in males, highlighting the need for personalized cardiovascular risk assessment.
Answers are grounded in this paper and cite their sources.
Obesity may independently drive inflammation in suspected OSAS; leaves open sex-specific IL-6 effects of severe OSAS for prospective confirmation.
The interaction among obstructive sleep apnea syndrome (OSAS) severity, sex, and obesity on cardiovascular risk as determined by serum levels of C-reactive protein (CRP), interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) remains unclear. Therefore, this study aimed to analyze individual associations between these three OSAS characteristics and three cardiovascular biomarkers and to determine whether the relationship was affected by other features in patients with suspected OSAS. For all participants (n = 100), OSAS severity and sex had an interaction effect on IL-6 level (p = 0.030). Specifically, the male patients (p = 0.005) with severe OSAS had higher IL-6 levels than those with normal to moderate OSAS, but this relationship was not significant in the female patients (p = 0.438). Moreover, in patients with normal to moderate OSAS (p = 0.004), but not in those with severe OSAS (p = 0.824), the female patients had higher IL-6 levels than the male patients. Both CRP (p = 0.001) and IL-6 (p = 0.000) levels were higher in the obese group than in the non-obese group independently of OSAS severity and sex. The three features had no effects on TNF-α level individually and interactively. Our findings suggest that circulatory inflammatory markers should be comprehensively evaluated in this population and that treatment and preventive therapies should be modified accordingly.
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Wu et al. (2020) conducted a cross-sectional in suspected obstructive sleep apnea syndrome (n=100). OSAS severity, sex, and obesity vs. normal to moderate OSAS, non-obese was evaluated on serum levels of CRP, IL-6, and TNF-α (p=0.030). Severe OSAS increased IL-6 levels in males (p=0.005) but not females, while obesity independently increased both CRP (p=0.001) and IL-6 (p<0.001) levels regardless of OSAS severity and sex.
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