Key result
Compatible symptoms in rhinovirus-positive children are linked to ~380% higher hospitalization odds versus incidental detection.
Why the study?
The role of rhinoviruses in children presenting with clinical syndromes not classically associated with rhinovirus infections is not well understood.
Does the presence of compatible symptoms correlate with increased disease severity in children who are PCR-positive for rhinovirus?
Population
2473 children ≤21 years old who were PCR+ for RV at a large Pediatric Hospital
Comparison
Children with compatible symptoms vs incidental RV detection
Design
Cohort study
Authors
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Compatible symptoms may distinguish pathogenic rhinovirus infection from incidental detection in children; leaves open whether symptom-guided testing improves outcomes.
Cohort (n=2,473)
No
Does the presence of compatible symptoms correlate with increased disease severity in children who are PCR-positive for rhinovirus?
Effect estimate: OR 4.8 (95% CI 3.1-7.4)
In children with rhinovirus, disease severity is significantly worse in those with compatible symptoms compared to incidental detection, despite comparable viral loads.
Sánchez-Códez et al. (2021) conducted a cohort in Rhinovirus-Associated Illnesses (n=2,473). Presence of compatible symptoms vs. Incidental rhinovirus detection (no compatible symptoms) was evaluated on Hospitalization (OR 4.8, 95% CI 3.1-7.4). The presence of compatible symptoms in rhinovirus-positive children independently increased the odds of hospitalization (OR 4.8; 95% CI 3.1-7.4) compared to incidental detection.
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