Key result
A febrile state unmasked Brugada syndrome electrocardiographic anomalies in a 66-year-old woman, which were subsequently reproduced by procainamide administration.
Case Report (n=1)
Fever can act as a trigger to unmask Brugada syndrome, leading to life-threatening arrhythmias that may require ICD implantation.
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May warrant ECG vigilance during fever in at-risk patients; leaves open generalizability from this Level 5 case report.
This case report describes a 66-year-old woman with severe polymorphic ventricular tachycardia and syncope during a febrile state. The electrocardiogram revealed a right bundle branch block and pattern of elevated ST segment in the anterior and inferior leads similar to the Brugada syndrome. These electrocardiographic anomalies disappeared when the temperature returned to normal. The administration of procainamide reproduced the electrocardiographic changes. An electrophysiological study using two extrastimuli induced ventricular tachycardia. An automatic defibrillator was implanted.
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Porres et al. (2002) conducted a case report in Brugada syndrome (n=1). Procainamide was evaluated. A febrile state unmasked Brugada syndrome electrocardiographic anomalies in a 66-year-old woman, which were subsequently reproduced by procainamide administration.
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